文献类型：期刊文献

中文题名：Two-step continuous flow process of sodium tanshinoneⅡA sulfonate using a 3D circular cyclone-type microreactor

作者：Maolin Sun[1,2];Chaoming Liang[1];Liming Cao[2];Yaguo Wang[1];Jiasheng Yang[2];Shiyu Hou[3];Wei Yu[2,4];Yueyue Ma[1];Ruihua Cheng[1];Jinxing Ye[1,2]

机构：[1]School of Biomedical and Pharmaceutical Sciences,Guangdong University of Technology,Guangzhou 510006,China;[2]School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;[3]School of Chemical Engineering,East China University of Science and Technology,Shanghai 200237,China;[4]Shanghai No.1 Biochemical&Pharmaceutical Co.,Ltd.,Shanghai 200080,China

年份：2024

卷号：35

期号：1

起止页码：290

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报(英文版)

收录：CSTPCD;;Scopus;CSCD:【CSCD2023_2024】；PubMed;

基金：the National Natural Science Foundation of China(No.22278087)。

语种：英文

中文关键词：Continuous flow;Sodium tanshinone IIA sulfonate;Cardiovascular;Microreactor;Green chemistry

摘要：A sustainable and practical process is presented for the direct synthesis of sodium tanshinone IIA sulfonate(STS).Our approach was inspired by the well-established and industrially applied batch synthetic route for STS production.We constructed a telescoped two-step continuous flow platform.This involved a continuous tanshinone IIA sulfonation and in-line salt formation.For the setup,we constructed a 3D circular cyclone-type microreactor using femtosecond laser micromachining.Compared to the 68%yield for 2 h in batch,the two-step continuous flow had an STS yield of 90%,achieved for a total residence time of<3.0 min under optimal conditions.The proposed continuous flow method vastly simplified the operation and improved procedural safety,while significantly reducing the required acid content and wastewater production.