文献类型：期刊文献

英文题名：A New Work Mechanism on Neuronal Activity

作者：Wang, Rubin[1,2,3];Tsuda, Ichiro[3];Zhang, Zhikang[1,2]

机构：[1]E China Univ Sci & Technol, Sch Sci, Inst Cognit Neurodynam, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Informat Sci & Engn, Shanghai 200237, Peoples R China;[3]Hokkaido Univ, Res Inst Elect Sci, Kita Ku, Sapporo, Hokkaido 0010012, Japan

年份：2015

卷号：25

期号：3

外文期刊名：INTERNATIONAL JOURNAL OF NEURAL SYSTEMS

收录：;EI(收录号：20151800805841);WOS:【SCI-EXPANDED(收录号:WOS:000352640100001)】；

基金：This work was supported by the National Natural Science Foundation of China (NSFC) (11232005, 11472104), the Fundamental Research Funds for the Central Universities of China and The Ministry of Education Doctoral Foundation (20120074110020), and the Japan Society for Promotion of Science (JSPS Fellow).

语种：英文

外文关键词：Action potential; information coding; neuronal energy coding; negative neuronal energy; neural energy field

摘要：By re-examining the neuronal activity energy model, we show the inadequacies in the current understanding of the energy consumption associated with neuron activity. Specifically, we show computationally that a neuron first absorbs and then consumes energy during firing action potential, and this result cannot be produced from any current neuron models or biological neural networks. Based on this finding, we provide an explanation for the observation that when neurons are excited in the brain, blood flow increases significantly while the incremental oxygen consumption is very small. We can also explain why external stimulation and perception emergence are synchronized. We also show that negative energy presence in neurons at the sub-threshold state is an essential reason that leads to blood flow incremental response time in the brain rather than neural excitation to delay.