文献类型：期刊文献

英文题名：Electrospun PLGA membrane incorporated with andrographolide-loaded mesoporous silica nanoparticles for sustained antibacterial wound dressing

作者：Jia, Yuhang[1];Zhang, Hongbo[1];Yang, Shengbing[2];Xi, Zhenhao[3];Tang, Tingting[2];Yin, Ruixue[1];Zhang, Wenjun[1,4]

机构：[1]East China Univ Sci & Technol, Sch Mech & Power Engn, Complex & Intelligent Syst Res Ctr, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Orthopaed Surg, Shanghai Key Lab Orthopaed Implants,Sch Med, Shanghai 200011, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China;[4]Univ Saskatchewan, Div Biomed Engn, Saskatoon, SK S7N 5A2, Canada

年份：2018

卷号：13

期号：22

起止页码：2881

外文期刊名：NANOMEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000452397600006)】；

基金：This work was funded by the National Science Foundation of China (21676083, 81802178); Shanghai Lianmeng Gant (LM201603); The Opening project of Shanghai Key Laboratory of Orthopedic Implant (KFKT2018001); the Grant awarded by Biomedical Engineering Crossover Project of Shanghai Jiao Tong University (YG2014ZD01); China Postdoctoral Science Foundation (2015M571574) and Science and Technology Commission of Shanghai Municipality (18441902700). The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.

语种：英文

外文关键词：andro-loaded MSNs; antibacteria; biocompatibility; electrospinning; histological analysis; hydrophilicity; prolonged antibacterial function; sustained release; wound dressing

摘要：Aim: To assess the wound-healing ability of poly(lactic-co-glycolic acid) (PLGA) nanofibrous wound dressing incorporated with andrographolide (Andro)-loaded mesoporous silica nanoparticles (MSNs). Materials & methods: PLGA/Andro-MSNs nanofibrous membrane wound dressings were produced by electrospinning. The effects of MSNs on the hydrophilicity, degradation and mechanical strength of membranes were evaluated. The cumulative release of Andro in vitro was obtained. Cell culture and in vivo tests on infectious models were carried out. Results: The PLGA/Andro-MSNs membrane showed a sustained release of Andro. The incorporation of MSNs into PLGA improved the hydrophilicity of the nanofibrous membranes. Cell culture and in vivo tests showed that PLGA/Andro-MSNs membrane can promote epidermal cell adhesion and reduce inflammation process. Conclusion: PLGA/Andro-MSNs nanofibrous membrane exhibited an efficient wound-healing ability. [GRAPHICS] .