文献类型：期刊文献

英文题名：FeCl3-catalyzed selective acylation of amines with 1,3-diketones via C-C bond cleavage

作者：Wang, Sinan[1,2,3];Yu, Yang[1,2];Chen, Xuyun[1,2];Zhu, Haipan[4];Du, Peile[4];Liu, Guohua[4];Lou, Liguang[3];Li, Hao[1,2];Wang, Wei[1,2,5]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;[4]Shanghai Normal Univ, Minist Educ, Key Lab Resource Chem, Shanghai 200234, Peoples R China;[5]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2015

卷号：56

期号：23

起止页码：3093

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000356544800028)，CCR-EXPANDED(收录号:WOS:000356544800028)】；

语种：英文

外文关键词：FeCl3; Acylation; 1,3-Diketones; C-C bond cleavage

摘要：We describe a novel FeCl3 catalyzed selective acylation of amines involving the C-C bond cleavage of simple 1,3-diketones. The process proceeds efficiently under a neat condition to give structurally diverse amides. Notably, the acylation process displays high selectivity toward amines over hydroxyl functionality. Traditionally difficult aromatic amines and sterically demanding disubstituted amines can engage in the process with high efficiency. (C) 2015 Elsevier Ltd. All rights reserved.