文献类型：期刊文献

英文题名：Gold(I)-catalyzed synthesis of β-Kdo glycosides using Kdo ortho-hexynylbenzoate as donor

作者：Mi, Xuemeng[1];Lou, Qixin[1];Fan, Wenjing[1];Zhuang, Liqin[1];Yang, You[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2017

卷号：448

起止页码：161

外文期刊名：CARBOHYDRATE RESEARCH

收录：;EI(收录号：20171903644593);WOS:【SCI-EXPANDED(收录号:WOS:000407665100025)，CCR-EXPANDED(收录号:WOS:000407665100025)】；

基金：Financial support from the National Thousand Young Talents Program (YC0130518, YC0140103), Shanghai Pujiang Program (1591401500), the Fundamental Research Funds for the Central Universities (WY1514052), and the State Key Laboratory of Bioorganic and Natural Products Chemistry (Y100-D-1501), is gratefully acknowledged.

语种：英文

外文关键词：Glycosylation; Gold; Kdo; Glycosyl ortho-hexynylbenzoate; Synthetic methods

摘要：A gold(I)-catalyzed glycosylation of Kdo with glycosyl ortho-hexynylbenzoate as donor is reported. The couplings of Kdo ortho-hexynylbenzoate with a set of alcohols promoted by PPh3AuOTf afford Kdo glycosides with good beta-selectivities. This glycosylation method allows for the synthesis of beta-Kdo monosaccharide with a C5 linker at the reducing end for subsequent conjugation to carrier proteins and arrays. (C) 2017 Elsevier Ltd. All rights reserved.