文献类型：期刊文献

英文题名：Well-defined and biocompatible hydrogels with toughening and reversible photoresponsive properties

作者：Sun, Zhiqiang[1];Liu, Shunli[1];Li, Kewen[1];Tan, Linhua[2,3];Cen, Lian[2,3];Fu, Guodong[1]

机构：[1]Southeast Univ, Sch Chem & Chem Engn, Nanjing 211189, Jiangsu, Peoples R China;[2]E China Univ Sci & Technol, Sch Chem Engn, Dept Product Engn, Shanghai Key Lab Multiphase Mat Chem Engn, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[3]Natl Tissue Engn Ctr China, 68 East Jiang Chuan Rd, Shanghai 200241, Peoples R China

年份：2016

卷号：12

期号：7

起止页码：2192

外文期刊名：SOFT MATTER

收录：;EI(收录号：20160701954346);WOS:【SCI-EXPANDED(收录号:WOS:000370425200027)】；

基金：This work was supported by National Natural Science Foundation of China under the grant 21274020, 21074022 and 21304019. This work was also supported by the Key Laboratory of Environmental Medicine Engineering of Ministry of Education (Southeast University), National "973'' Project Foundation of China (Grant no. 2010CB944804) and "the Fundamental Research Funds for the Central Universities''.

语种：英文

外文关键词：Biocompatibility - Irradiation - Polyols - Hydrophilicity - Copper compounds - Polyethylene glycols

摘要：In the present study, novel hydrogels with extremely high strength, reversible photoresponsive and excellent biocompatible properties were prepared. The functional hydrogels were synthesized from a well-defined poly (ethylene glycol) polymer with spiropyran groups at a given position (PEG-SP) via a Cu(I)-catalyst Azide-Alkyne Cycloaddition (CuAAC) reaction. The molecular structures of the sequential intermediates for PEG-SP hydrogel preparation were verified by (HNMR)-H-1 and FT-IR. The mechanical property, swelling ratio, compression strength, surface hydrophilicity, and biocompatibility of the resulting hydrogel were characterized. Since spiropyran is pivotal to the switch in hydrophilicity on the hydrogel surface, the swelling ratio of PEG-SP hydrogel under Vis irradiation has a major decrease (155%). Before and after UV light irradiation, the contact angle of the hydrogel has a change of 13.8 degrees. The photoresponsive property of this hydrogel was thus demonstrated, and such a property was also shown to be reversible. The well-defined PEG-SP hydrogel can also sustain a compressive stress of 49.8 MPa without any macro-or micro-damage, indicating its outstanding mechanical performance. Furthermore, it possessed excellent biocompatibility as demonstrated by its performance in an in vivo porcine subcutaneous implantation environment. No inflammation was observed and it got along well with the adjacent tissue. The above features indicate that PEG-SP hydrogels are promising as an implantable matrix for potential applications in biomaterial.