文献类型：期刊文献

英文题名：Silica-based nanoplatforms for nucleic acid delivery: Emerging strategies and biomedical applications

作者：Li, Xilong[1];Bai, Yacheng[1];Zhang, Dapeng[1];Li, Yongsheng[1]

机构：[1]East China Univ Sci & Technol, Frontier Sci Ctr Mat Biol & Dynam Chem, Shanghai Engn Res Ctr Hierarch Nanomat,Key Lab Ult, Sch Mat Sci & Engn,Lab Low Dimens Mat Chem, Shanghai 200237, Peoples R China

年份：2026

卷号：70

外文期刊名：NANO TODAY

收录：;EI(收录号：20262821097057);Scopus(收录号：2-s2.0-105044425561);WOS:【SCI-EXPANDED(收录号:WOS:001788611400001)】；

基金：This work was financially supported by the National Natural Science Foundation of China (Nos. 22305081, 32571562, 52572303) , Leading Talents in Shanghai in 2018, Shanghai Sailing Program (23YF1408600) , the 111 project (B14018) , and the Fundamental Research Funds for the Central Universities of China.

语种：英文

外文关键词：Nucleic acid delivery; Silica nanocarriers; Loading strategies; Responsive mechanisms; Biological applications

摘要：Nucleic acid therapeutics are transforming modern medicine to a new era, yet their intrinsic instability, immunogenicity, and poor intracellular transport continue to limit clinical translation. Although lipid-based nanoparticles have driven recent successes, formulation constraints such as cold-chain dependence and particle instability motivate complementary solutions. Silica-based nanomaterials provide a robust alternative due to their structurally programmable architectures, large accessible surface area, and chemically accessible silanol network, enabling rational tuning of nucleic acid loading, stabilization, and biodistribution. However, existing relevant studies remain fragmented and lack clear summary to provide generalizable design rules. This review integrates current progress and establishes a coherent conceptual basis connecting foundational considerations of carrier systems, NA loading strategies, stimuli-responsive release mechanisms, and therapeutic functions. By emphasizing physicochemical compatibility between silica matrices and NA cargos, we outline actionable design principles to guide the development of next-generation bio-modulatory silica platforms-especially for emerging RNA therapeutics.