文献类型：期刊文献

英文题名：Catalytic asymmetric synthesis of 3-hydroxyl-2-oxindoles via enantioselective Morita-Baylis-Hillman reaction of isatins

作者：Wang, Ci-Ci;Wu, Xin-Yan[1]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2011

卷号：67

期号：16

起止页码：2974

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000289862700022)，CCR-EXPANDED(收录号:WOS:000289862700022)】；

基金：We are grateful for the financial support from National Natural Science Foundation of China (20772029), the Program for New Century Excellent Talents in University (NCET-07-0286), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Enantioselective organocatalysis; Morita-Baylis-Hillman reaction; Bifunctional phosphinothiourea; Isatin; 3-Hydroxyl-2-oxindole

摘要：The enantioselective Morita-Baylis-Hillman reaction of acrylates to isatins was investigated for the first time, employing bifunctional phosphinothiourea organocatalysts based on chiral cyclohexane scaffold. The 3-hydroxyl-2-oxindole derivatives were obtained in excellent yields with moderate enantioselectivity (up to 69% ee) in the presence of 10 mol % catalyst 1b. (C) 2011 Elsevier Ltd. All rights reserved.