文献类型：期刊文献

英文题名：Enantioselective vinylogous aldol/lactonization cascade reaction between β,γ-unsaturated amides and trifluoromethyl ketones: facile access to chiral trifluoromethyl dihydropyranones

作者：Fu, Jun-Hao[1,2];Zhang, Zhen-Guo[1,2];Zhou, Xue-Ying[1,2];Fu, Chun-Wei[1,2];Sha, Feng[1,2];Wu, Xin-Yan[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2020

卷号：18

期号：39

起止页码：7848

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20204409428010);WOS:【SCI-EXPANDED(收录号:WOS:000579572100013)】；

基金：We are grateful for the financial support from the Natural Science Foundation of Shanghai (19ZR1412300), Shanghai Pujiang Program (18PJD010) and the Fundamental Research Funds for the Central Universities (222201814019).

语种：英文

外文关键词：Enantioselectivity - Ketones

摘要：An efficient asymmetric vinylogous aldol/lactonization cascade reaction between beta,gamma-unsaturated amides and trifluoromethyl ketones has been developed. Using a chiral cyclohexanediamine-based tertiary amine-thiourea catalyst, optically active trifluoromethyl dihydropyranones have been constructed in moderate-to-excellent yields (up to 99%) with excellent stereoselectivities (96-> 99.5% ee).