文献类型：期刊文献

英文题名：Continuous micro feeding and mixing of solid dosage forms under vibrational excitation

作者：Lu, Haifeng[1];Zhang, Liang[1];Du, Hui[1];Guo, Xiaolei[1];Liu, Haifeng[1]

机构：[1]East China Univ Sci & Technol, Natl Energy Coal Gasificat Technol Res & Dev Ctr, State Key Lab Coal Liquificat, Gasificat & Utilizat High Efficiency & Low Carbon, Shanghai 200237, Peoples R China

年份：2025

卷号：301

外文期刊名：CHEMICAL ENGINEERING SCIENCE

收录：;EI(收录号：20243717023649);WOS:【SCI-EXPANDED(收录号:WOS:001313765700001)】；

基金：The authors acknowledge financial support from the National Nat-ural Science Foundation of China (51876066) and the Shanghai Engi-neering Research Center of Coal Gasification (18DZ2283900) .

语种：英文

外文关键词：Continuous manufacturing; Cohesive powders; Hopper discharge; Localized vibration; Continuous mixing

摘要：Continuous manufacturing has intrigued many researchers in the pharmaceutical industry in the post-COVID-19 world. We experimentally studied the discharge characteristics of pharmaceutical excipients under vibrational excitation. The successful accurate dosing and filling of powders at fill rates of 0.6-15 mg/s was developed. A simple particle model includes fluid-grain coupling which is relevant to Faraday tilting resulting from gas trapped in the powder bed accurately predicts the discharge rate. A novel continuous micro mixing system was designed based on the discharge model. Any specified proportions can be realized by setting appropriate vibration parameters. The low variability (<2.5 %) in the content of components has verified the reliability of the mixing system. The continuous mixing performance was determined by the discharge characteristics. Yet the particle size distribution and cohesion lead to different mixing performances when the stability of micro feeding is satisfied. Reasonable process parameters for continuous mixing are determined and optimized.