文献类型：期刊文献

英文题名：Two-step synthesis of vicinal trifluoromethyl primary amines from α-(trifluoromethyl)styrenes and phthalimide

作者：Liu, Ying[1];Huang, Jiaqi[1];Sun, Zhudi[1];Deng, Yupian[1];Qian, Yuhao[1];Huang, Qingchun[1];Cao, Song[1,2]

机构：[1]East China Univ Sci & Technol ECUST, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

年份：2024

卷号：22

期号：23

起止页码：4641

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20242216152385);WOS:【SCI-EXPANDED(收录号:WOS:001228772600001)，CCR-EXPANDED(收录号:WOS:001228772600001)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (grant no. 32372588).

语种：英文

外文关键词：Amines

摘要：A novel two-step synthesis of beta-trifluoromethyl primary amines from readily available alpha-(trifluoromethyl)styrenes and phthalimide is developed. The first step involves a hydroamination between alpha-(trifluoromethyl)styrenes and phthalimide (PhthNH) with the assistance of a base. Next, the hydrazinolysis of the resulting N-(beta-trifluoromethyl-beta-arylethyl)phthalimides with hydrazine hydrate affords the desired N-(beta-trifluoromethyl-beta-arylethyl)amines. A two-step synthesis of beta-CF3 primary amines from a-CF3-styrenes and phthalimide is developed. The first step involves hydroamination of a-CF3-styrenes with phthalimide. Next, hydrazinolysis of the hydroamination products affords the beta-CF3 amines.