文献类型：期刊文献

英文题名：Cu(II)-catalyzed one-pot synthesis of fully substituted dihydrothiophenes and thiophenes from thioamides and enynones

作者：Wen, Min[1];Sun, Pei-Pei[1];Luo, Xiaoyan[1];Deng, Wei-Ping[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2018

卷号：74

期号：31

起止页码：4168

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000439403400003)，CCR-EXPANDED(收录号:WOS:000439403400003)】；

基金：This work was financially supported by Natural Science Foundation of Shanghai (No. 17ZR1407600).

语种：英文

外文关键词：Cu(II)-Catalyzed; Dihydrothiophenes; Thiophenes; Thioamides; Enynones

摘要：A facile and direct synthetic method was developed for the construction of fully substituted dihydrothiophenes, which via a copper-catalyzed Michael addition/intramolecular cyclization/protonation cascade reaction of readily available thioamides with enynones under air atmosphere. This approach provides 2,3-dihydrothiophenes with up to 92% yield in a one-pot process. In addition, several fully substituted thiophenes could also be synthesized by changing the substituents of thioamides. (c) 2018 Published by Elsevier Ltd.