文献类型：期刊文献

英文题名：Facile Creation of 3-Indolyl-3-hydroxy-2-oxindoles by an Organocatalytic Enantioselective Friedel-Crafts Reaction of Indoles with Isatins

作者：Deng, Jing[1];Zhang, Shilei[2];Ding, Peng[1];Jiang, Hualiang[1,3];Wang, Wei[1,2,3];Li, Jian[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA;[3]Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, Shanghai 201203, Peoples R China

年份：2010

卷号：352

期号：5

起止页码：833

外文期刊名：ADVANCED SYNTHESIS & CATALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000276317800004)，CCR-EXPANDED(收录号:WOS:000276317800004)】；

基金：We are grateful for the financial support from the National Natural Science Foundation of China (Grants 90813005 and 20902022, J. Li), the 863 Hi-Tech Program of China (Grant 2006AA020404, J. Li), the China 111 Project (Grant 807023, J. Li and W. Wang) and the NSF (CHE-0704015 W Wang). Thanks are expressed to Dr Eileen N. Duesler for performing the X-ray analysis. The Bruker X8 X-ray diffractometer was purchased via an NSF CRIF:MU award to the University of New Mexico, CHE-0443580.

语种：英文

外文关键词：asymmetric Friedel-Crafts reaction; indoles; isatins; organocatalysis

摘要：The first direct enantioselective Friedel-Crafts reaction of indoles with isatins has been developed. The process is catalyzed by simple cupreine under mild reaction conditions and affords synthetically and biologically interesting, chiral 3-indolyl-3-hydroxy-2-oxindoles in good yields (68-97%) and with high enantioselectivities (76-91%).