文献类型：期刊文献

英文题名：Facile preparation of polyvinyl alcohol coated SiO2 stationary phases for high performance liquid chromatography

作者：Ji, Shunli[1];Zhang, Feifang[1];Wu, Shengjie[1];Yang, Bingcheng[1];Liang, Xinmiao[1,2]

机构：[1]East China Univ Sci Tech, Sch Pharm, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

年份：2014

卷号：139

期号：21

起止页码：5594

外文期刊名：ANALYST

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000343003700038)】；

基金：The research was sponsored by National Natural Science Foundation of China (no. 21177040, 21322502) and the Ministry of Science and Technology of China (2012YQ090229).

语种：英文

摘要：A facile method to prepare a polar stationary phase for hydrophilic interaction chromatography (HILIC) was proposed by coating polyvinyl alcohol onto silica particles (PVA-Sil). A water or organic solvent-insoluble permanent PVA coating on the silica particle surface can be formed simply by dipping silica particles into a hot PVA solution and then settled from this solution, leaving a thin layer of PVA coating and frozen in a freezer. The PVA-Sil shields the silica core from solution erosion to some degree and the pH tolerance range was extended to 9.5 from 8.0 for bare silica. PVA-Sil demonstrated a good hydrophilic property for several kinds of polar compounds and similar to 57000 m(-1) of plate count was achieved. This method can also be extended as a universal method to prepare various stationary phases with exchangeable functionalities by doping the desired ingredient in a PVA solution.