文献类型：期刊文献

英文题名：Chrysin Improves Glucose and Lipid Metabolism Disorders by Regulating the AMPK/PI3K/AKT Signaling Pathway in Insulin-Resistant HepG2 Cells and HFD/STZ-Induced C57BL/6J Mice

作者：Zhou, Ying-Jun[1];Xu, Nuo[1];Zhang, Xiao-Chen[1];Zhu, Yu-Yan[1];Liu, Shao-Wei[1];Chang, Ya-Ning[1]

机构：[1]East China Univ Sci & Technol, Coll Bioengn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2021

卷号：69

期号：20

起止页码：5618

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20212110400607);WOS:【SCI-EXPANDED(收录号:WOS:000657225400005)】；

语种：英文

外文关键词：AKT; AMPK; chrysin; glucose metabolism; lipid metabolism

摘要：Natural products with minor side effects have been reported to be an effective adjuvant therapy for glucose and lipid metabolism disorders. Chrysin, a flavone, has a wide range of physiological effects, such as antioxidant, anti-inflammatory, anti-diabetes, anti-hyperlipidemia, and hepatoprotective. This study was designed to explore the effects and mechanism of chrysin on metabolic syndrome using insulin-resistant HepG2 cells and HFD/STZ-induced C57BL/6J mice. The results indicated that chrysin significantly decreased insulin resistance, oxidative stress, inflammation, and liver injury. In addition, chrysin improved glycogen synthesis and fatty acid oxidation and inhibited gluconeogenesis and fatty acid synthesis by regulating GSK3 beta, G6Paes, PEPCK, SREBP1, FAS, and ACC1. Furthermore, the results of western blot and real-time PCR experiments demonstrated that chrysin modulated glucose and lipid metabolism through the AMPK/PI3K/AKT signaling pathway. Treatment with the AMPK inhibitor verified that AMPK activation is positively correlated with chrysin activity on glycolipid metabolism. This study confirms that chrysin is a potential treatment for glucose and lipid metabolism disorders.