文献类型：期刊文献

英文题名：Antibacterial, antioxidant and anti-inflammatory PLCL/gelatin nanofiber membranes to promote wound healing

作者：Li, Ang[1,2];Li, Linhui[3];Zhao, Bin'an[1];Li, Xiaotong[4];Liang, Wencheng[5];Lang, Meidong[5];Cheng, Biao[1];Li, Jun[1]

机构：[1]Tongji Univ, Shanghai Peoples Hosp 10, Dept Orthoped, 301 Yanchang Rd, Shanghai 200072, Peoples R China;[2]Shanghai Univ Tradit Chinese Med, Affiliated Shanghai Shuguang Hosp, Dept Gen Surg, 528 Zhangheng Rd, Shanghai 201203, Peoples R China;[3]Naval Med Univ, Affiliated Hosp 1, Dept Burns, 168 ChanghaiRd, Shanghai 200433, Peoples R China;[4]Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China;[5]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat,Minist Educ, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2022

卷号：194

起止页码：914

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：;EI(收录号：20235015203520);WOS:【SCI-EXPANDED(收录号:WOS:000734362300003)】；

基金：This work was financially supported by "The Innovation Action Plan of Science and Technology Commission of Shanghai Municipality of China (Grant No. 20S31901400, 19441901700, 19441901701, 19441901702)".

语种：英文

外文关键词：Gelatin; Nanofiber membrane; Drug sustained released system; Antibacterial; Antioxidant; Wound healing

摘要：Epigallocatechin-3-O-gallate (EGCG) is a green biomedical agent for promoting wound healing, which possess excellent antibacterial, antioxidant and anti-inflammatory activities. For improving the low bioavailability challenges of EGCG in vivo, we had successful created a low-cost and simple wound dressing Poly (L-Lactic-cocaprolactone) (PLCL)/Gelatin/EGCG/Core-shell nanofiber membrane (PGEC) with drug sustained release capacity through coaxial electrospinning technology. In vitro experimental indicated that the core-shell structure wound dressing had excellent biocompatibility, antibacterial and antioxidant ability, which could support cell viability and proliferation, encourage re-epithelialization during the healing process, inhibit subsequent wound infection and thus promote wound regeneration. In vivo experimental demonstrated that PGEC wound dressing could promote wound healing, the histological results further demonstrated that PGEC not only facilitated early wound closure but also influenced cellular differentiation and tissue organization. Meanwhile, PGEC had excellent hemostatic ability. Taken all together, we believed that the PGEC wound dressing, which could localize delivery of EGCG, had high potential clinical application for promoting wound healing, hemostasis or other related clinical applications in the future.