文献类型：期刊文献

英文题名：Copper-mediated direct thiolation of aryl C-H bonds with disulfides

作者：Deng, Ke-Zuan[1];Zhang, Li-Li[1];Chen, Ye-Feng[1];Xie, He-Xin[1];Xu, Xiao-Bo[1,2];Xia, Cheng-Cai[3];Ji, Ya-Fei[1]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Shanghai Key Lab New Drug Design,Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Shanghai Synmedia Chem Co Ltd, 526 Ruiqing Rd, Shanghai 201201, Peoples R China;[3]Shandong First Med Univ & Shandong Acad Med Sci, Pharm Coll, 619 Changcheng Rd, Tai An 271016, Shandong, Peoples R China

年份：2019

卷号：17

期号：29

起止页码：7055

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20193007236661);WOS:【SCI-EXPANDED(收录号:WOS:000476908500016)，CCR-EXPANDED(收录号:WOS:000476908500016)】；

基金：We gratefully thank the National Natural Science Foundation of China (NSFC, project no. 21476074 and 21676088) for financial support.

语种：英文

外文关键词：Amides - Sulfur compounds - Additives

摘要：An efficient copper-mediated ortho-C(sp(2))-H thiolation of aromatic amides directed by a novel directing group [4-chloro-2-(1H-pyrazol-1-yl)phenyl]amine has been developed without the need of other additives or oxidants, allowing for an increased usefulness. With the high compatibility of sterically demanding substrates, this reaction is scalable and can tolerate a wide scope of functional groups to provide alkyl and aryl thioethers in good to excellent yields (up to 93%). Furthermore, the protocol has been successfully implemented for the selenylation as well.