文献类型：期刊文献

中文题名：Effects of Hydrophobicity of Ethylene Oxide-Propylene Oxide Copolymers on Phase Diagrams of Aqueous Two-Phase Systems and Partition Behaviors of Cephalexin and 7-Aminodeacetoxicephalos Doranic Acid

作者：朱建航[1];魏东芝[1];曹学君[1];

机构：[1]State Key Laboratory of Bioreactor Engineering, Institute of Biochemistry, East China University of Science and Technology, Shanghai 200237, China;

年份：2002

卷号：10

期号：2

中文期刊名：中国化学工程学报(英文版)

外文期刊名：CHINESE JOURNAL OF CHEMICAL ENGINEERING

基金：国家自然科学基金，the Key Disciplinary Foundation of Shanghai

语种：中文

外文关键词：ethylene oxide (EO) and propylene oxide (PO) random co-polymer (EOPO);aqueous two-phase sys-telns;partition coefficient;phase diagram;cephalexin

摘要：A series of ethylene oxide (EO)-propylene oxide (PO) random co-polymers (EOPO) were used to formaqueous two-phase systems (ATPS) with ammonium sulfate. Effects of EOPO's properties on the phase separationbehaviors and on the partition of cephalexin and 7-aminodesacetoxicephalosporanic acid (7-ADCA) in ATPS wereinvestigated. Both the molar mass and molar ratio of EO to PO of EOPO could greatly influence partition behaviorsof cephalexin and 7-ADCA as well as the binodal curve of ATPS. With the increase of molar mass of co-polymeror the decrease of molar ratio of EO to PO, the critical point of ATPS decreased, the binodal curve became moreasymmetry, and both cephalexin and 7-ADCA followed the same tendency to partition into the polymer-poorbottom phase. The experimental results shows that it is feasible to partition cephalexin and 7-ADCA in either thepolymer-rich top phase or the polymer-poor bottom phase by choosing a specific phase-forming EOPO.