文献类型：期刊文献

中文题名：G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders

作者：Thian-Sze Wong[1,2];Guangzhi Li[3];Shiliang Li[4,5];Wei Gao[1,5];Geng Chen[1];Shiyi Gan[1];Manzhan Zhan[4,5];Honglin Li[4,5];Song Wu[3,6];Yang Du[1]

机构：[1]Kobilka Institute of Innovative Drug Discovery,Shenzhen Key Laboratory of Steroid Drug Discovery and Development,School of Medicine,The Chinese University of Hong Kong,518172,Shenzhen,Guangdong,China;[2]School of Medicine,Tsinghua University,100084,Beijing,China;[3]Institute of Urology,The Affiliated Luohu Hospital of Shenzhen University,Shenzhen University,518000,Shenzhen,Guangdong,China;[4]Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science and Technology,200237,Shanghai,China;[5]Innovation Center for AI and Drug Discovery,East China Normal University,200062,Shanghai,China;[6]Department of Urology,South China Hospital,Health Science Center,Shenzhen University,518116,Shenzhen,Guangdong,China

年份：2023

卷号：8

期号：6

起止页码：2493

中文期刊名：Signal Transduction and Targeted Therapy

外文期刊名：信号转导与靶向治疗（英文）

收录：CSTPCD;;Scopus;CSCD:【CSCD2023_2024】；PubMed;

基金：supported by grants from Science,Technology and Innovation Commission of Shenzhen Municipality(Project code JCYJ20200109150019113,GXWD20201231105722002);the Kobilka Institute of Innovative Drug Discovery and Presidential Fellowship at the Chinese University of Hong Kong,Shenzhen,China;National Natural Science Foundation of China(Project code 32271263 to Y.D.,Project code 82173690 to S.L.,81825020 and 82150208 to H.L.);the Lingang Laboratory(Project code LG-QS-202206-02 to S.L.)。

语种：英文

中文关键词：psychiatric;disorders;diseases;

摘要：Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.Identifying treatment targets is challenging because the diseases are resulting from heterogeneous biological,genetic,and environmental factors.Nevertheless,the increasing understanding of G protein-coupled receptor(GPCR)opens a new possibility in drug discovery.Harnessing our knowledge of molecular mechanisms and structural information of GPCRs will be advantageous for developing effective drugs.This review provides an overview of the role of GPCRs in various neurodegenerative and psychiatric diseases.Besides,we highlight the emerging opportunities of novel GPCR targets and address recent progress in GPCR drug development.