文献类型：期刊文献

英文题名：Microfluidic preparation of PLGA composite microspheres with mesoporous silica nanoparticles for finely manipulated drug release

作者：Zhou, Jiayu[1];Zhai, Yishu[1];Xu, Jumei[1];Zhou, Tian[2,3];Cen, Lian[1]

机构：[1]East China Univ Sci & Technol, Sch Chem Engn, Dept Prod Engn, Shanghai Key Lab Multiphase Mat Chem Engn, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Dept Oral Maxillofacial Head & Neck Oncol, Shanghai Key Lab Stomatol,Shanghai Peoples Hosp 9, Coll Stomatol,Sch Med,Natl Clin Res Ctr Oral Dis, Shanghai 200011, Peoples R China;[3]Shanghai Res Inst Stomatol, Shanghai 200011, Peoples R China

年份：2021

卷号：593

外文期刊名：INTERNATIONAL JOURNAL OF PHARMACEUTICS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000604746700042)】；

基金：This study is financially supported by the National Nature Science Foundation of China (81471855, 21676083).

语种：英文

外文关键词：Mesoporous silica nanoparticles; PLGA; Microspheres; Microfluidics; Drug release

摘要：The current study explored the feasibility of a microfluidic preparation of PLGA composite microspheres with mesoporous silica nanoparticles (MSNs) to finely manipulate the drug release behaviors of the microspheres. MSNs were synthesized via a hydrothermal method, and PLGA microspheres loaded with MSNs (PLGA-MSNs) were prepared using a capillary-based three-phase micmfluidic device. Drug loading and release behaviors using rhodamine B (RB) as a water-soluble model drug were investigated and compared with those of PLGA microspheres. MSNs with an average particle size of 119 nm, a specific surface area of 902.5 cm(2)/g, and a pore size of approximately 5 nm were obtained. The mean diameter of PLGA-MSNs was 56 mu m (CV = 4.91%). A sustained release duration of encapsulated RB from PLGA-MSNs for 4 months was achieved without any observable burst release. PLGA microspheres with monodispersion could also allow for a similar release duration of encapsulated RB but encountered a burst release in the mid-term of the studied duration. PLGA-MSNs had a denser outer PLGA layer and a more centralized hollow hole than PLGA microspheres without MSNs. Hence, the incorporation of MSNs into PLGA microspheres via microfluidics could be an efficient strategy to finely tune the drug release behavior of PLGA microspheres.