文献类型：期刊文献

英文题名：Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

作者：Yan, Kai-Cheng[1,2];Sedgwick, Adam C.[3];Zang, Yi[4];Chen, Guo-Rong[1,2];He, Xiao-Peng[1,2];Li, Jia[4];Yoon, Juyoung[5];James, Tony D.[6]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Univ Texas Austin, Dept Chem, 105 E 24th St A5300, Austin, TX 78712 USA;[4]Chinese Acad Sci, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai Inst Mat Med, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China;[5]Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea;[6]Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

年份：2019

卷号：3

期号：7

外文期刊名：SMALL METHODS

收录：;EI(收录号：20201408371709);WOS:【SCI-EXPANDED(收录号:WOS:000479005000002)】；

基金：K.-C.Y., Y.Z., G.-R.C., J.L., and X.-P.H. thank the National Natural Science Foundation of China (Grant Nos. 91853201, 21722801, 21776078, 81673489, and 81125023), the Shanghai Municipal Science and Technology Major Project (Grant No. 2018SHZDZX03) and Internation Cooperation Project (Grant No. 16430724100), the Programme of Introducing Talents of Discipline to Universities (B16017), and the K. C. Wong Education Foundation and the Fundamental Research Funds for the Central Universities (222201717003) for generous financial support. T.D.J. wishes to thank the Royal Society for a Wolfson Research Merit Award. J.Y. thanks the National Research Foundation of Korea (NRF), which was funded by the Korea government (MSIP) (Grant No. 2012R1A3A2048814).

语种：英文

外文关键词：fluorescence; imaging agents; ROS; sensors; theranostics

摘要：Reactive oxygen species (ROS) consist of a diverse range of oxidative small molecular ions and free radicals that are produced throughout the body during certain biological processes. Due to their high reactivity, these molecules result in the damage of tissues and cells. Therefore, ROS have been implicated in an array of diseases including cancer, inflammation, and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Owing to the simplicity, sensitivity, and selectivity of fluorescence-based strategies, many small-molecular sensors or imaging agents have been developed to sense and visualize ROS both in vitro and in vivo. Likewise, activatable drug delivery and prodrug systems that can be triggered by ROS for disease theranostics (diagnostic and therapeutic combined) have been developed. Herein, recently developed fluorescence-based sensing and imaging agents for the detection of ROS both intracellularly and in vivo are summarized. In addition, drug delivery, which require activation by ROS to achieve disease theranostics is also discussed.