文献类型：期刊文献

英文题名：Engineering a material for biomedical applications with electric field assisted processing

作者：Ahmad, Z.[1];Nangrejo, M.[1];Edirisinghe, M.[1];Stride, E.[1];Colombo, P.[1,2,3];Zhang, H. B.[4]

机构：[1]UCL, Dept Mech Engn, London WC1E 7JE, England;[2]Univ Padua, Dept Mech Engn & Mat Sci, I-35122 Padua, Italy;[3]Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA;[4]E China Univ Sci & Technol, Sch Mech & Power Engn, Shanghai 200237, Peoples R China

年份：2009

卷号：97

期号：1

起止页码：31

外文期刊名：APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING

收录：;EI(收录号：20093712295380);WOS:【SCI-EXPANDED(收录号:WOS:000269206600005)】；

基金：The authors are grateful to the Archaeology Department at University College London for use of their SEM equipment. We also acknowledge the EPSRC grant EP/E045839, Royal Academy of Engineering and the Leverhulme Trust (F/07134/BL) for supporting this work. Collaboration between UCL and the University of Padua was funded by the Royal Society and we wish to acknowledge the exchange visits made possible by this grant.

语种：英文

外文关键词：Targeted drug delivery - Microfluidics - Controlled drug delivery - Tissue engineering - Nanoparticles - Surface treatment - Network layers - Medical applications - Encapsulation

摘要：In this work, using multiple co-flows we demonstrate in-situ encapsulation of nano-particles, liquids and/or gases in different structural morphologies, which can also be deposited in a designated pattern by a direct write method and surface modification can be controlled to release encapsulated material. The range of possibilities offered by exposing a material solution to an applied electric field can result in a plethora of structures which can accommodate a whole host of biomedical applications from microfluidic devices (microchannels, loaded with various materials), printed 3D structures and patterns, lab-on-a-chip devices to encapsulated materials (capsules, tubes, fibres, dense multi-layered fibrous networks) for drug delivery and tissue engineering. The structures obtained in this way can vary in size from micrometer to the nanometer range and the processing is viable for all states of matter. The work shown demonstrates some novel structures and methodologies for processing a biomaterial.