文献类型：期刊文献

英文题名：Confined coordination regulation of rhodium in organosilica active framework for enhanced photothermal-enzymatic diabetic wound healing

作者：Yin, Xinwu[1];Zhang, Wancheng[1];Zhao, Lihua[1];Wu, Jinyong[1];Mao, Yeqiong[1];Yin, Siyuan[1];Niu, Zhihui[2];Zhang, Xinya[1];Li, Xiaowei[2];Niu, Dechao[1]

机构：[1]East China Univ Sci & Technol, Frontier Sci Ctr Mat Biol & Dynam Chem, Sch Mat Sci & Engn,Lab Low Dimens Mat Chem, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Shandong Univ Technol, Res Ctr Biomed Mat & Devices, Sch Mat Sci & Engn, Zibo 255000, Peoples R China

年份：2026

卷号：38

外文期刊名：MATERIALS TODAY BIO

收录：;EI(收录号：20261620529090);WOS:【SCI-EXPANDED(收录号:WOS:001750359700001)】；

基金：This work was financially supported by the National Natural Science Foundation of China (grant No. 32371406) , Key Program of National Natural Science Foundation of China Regional Joint Funds (No. U24A20376) , National Key Research and Development Program of China (No. 2022YFC2405702) , Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Coordination regulation; Organosilica framework; Rhodium; Nanozyme; Wound healing

摘要：The modulation and alteration of metal coordination structure is intricately associated with their biological activity. However, the precise control of metal active site in a matrix and thereby enhance the biological activity remains a great challenge. Herein, a convenient "reduction-mediated coordination regulation" strategy was proposed to construct novel rhodium-oxygen clusters in confined organosilica active framework ([RhO3]NC-FOMs) with enhanced photothermal-enzymatic properties for efficient and safe diabetic wound healing. Results revealed that coordination structure of Rh in organosilica-based matrix can be easily adjusted from [RhS2]NCFOMs to [RhO3]NC-FOMs by changing the reactive conditions from neutral to reductive environment. Simultaneously, the confined effect in physical space ensured uniform and stable [RhO3] coordination structure. Compared with [RhS2]NC-FOMs and other reported Rh-based materials, [RhO3]NC-FOMs demonstrated superior photothermal conversion efficiency exceeding 80% under 808 nm laser, along with remarkable POD/CAT/SODlike multi-enzymatic activities, thereby enhancing infected diabetic wound healing. This work provides a simple and effective strategy to regulate metal coordination structure for promising therapeutic applications.