文献类型：期刊文献

英文题名：Redox/ultrasound dual stimuli-responsive nanogel for precisely controllable drug release

作者：Shen, Nengwei[1];Lei, Bin[1];Wang, Yizhou[1];Xu, Shouhong[1];Liu, Honglai[1]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2018

卷号：42

期号：12

起止页码：9472

外文期刊名：NEW JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000435298100014)】；

基金：Financial support for this study was provided by the National Natural Science Foundation of China (No. 21776071) and the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002) and the 111 Project of China (No. B08021).

语种：英文

摘要：Ultrasound is expected to be utilized in stimuli-responsive drug delivery systems (DDS) since it is safe, non-invasive and easy to control. In this study, a novel nanogel system with a redox/ultrasound dual stimuli-response has been developed for precise control of drug release. First, a thermo-sensitive copolymer PEIm-PNIPAM(n)-PEIm self-assembled into micelles in aqueous solution above its LCST. Then, PEI gel shell was formed by using a disulfide-containing cross-linker and spherical nanogels were obtained. Perfluorohexane (PFH) was introduced into the nanogels to provide a cavitation effect under an ultrasound stimulus. Furthermore, the PEI gel shell was specifically disintegrated by glutathione (GSH). The effects of redox/ultrasound on the structure and drug release of the nanogels were investigated. The release rate was found to be accelerated by the above-mentioned factors and a complete release was realized almost instantly. The release mechanism of the nanogels was then investigated. The dual stimuli-responsive nanogels present a promising application prospect for precisely controllable drug delivery/release.