文献类型：会议论文

英文题名：Injectable bioactive calcium-magnesium phosphate cement for bone regeneration

作者：Wu, Fan[1,2];Su, Jiacan[3];Wei, Jie[1,2];Guo, Han[1,2];Liu, Changsheng[1,2]

机构：[1]E China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China;[3]Second Mil Med Univ, Changhai Hosp, Dept Orthopaed, Shanghai 200433, Peoples R China

会议论文集：5th China-Korea Symposium on Biomaterials and Nano-Biotechnology

会议日期：OCT 14-18, 2007

会议地点：Wuhan, PEOPLES R CHINA

语种：英文

外文关键词：Biodegradation - Magnesium compounds - Degradation - Setting - Calcium phosphate - Bone cement - Cements

摘要：Novel injectable and degradable calcium-magnesium phosphate cement (CMPC) with rapid-setting characteristic was developed by the introduction of magnesium phosphate cement (MPC) into calcium phosphate cement (CPC). The calcium-magnesium phosphate cement prepared under the optimum P/L ratio exhibited good injectability and desired workability. It could set within 10 min at 37 degrees C in 100% relative humidity and the compressive strength could reach 47 MPa after setting for 48 h, indicating that the prepared cement has relatively high initial mechanical strength. The results of in vitro degradation experiments demonstrated the good degradability of the injectable CMPC, and its degradation rate occurred significantly faster than that of pure CPC in simulated body fluid (SBF) solution. It can be concluded that the novel injectable calcium-magnesium phosphate cement is highly promising for a wide variety of clinical applications, especially for the development of minimally invasive techniques.