文献类型：期刊文献

英文题名：Copper-Catalyzed Cross-Dehydrogenative Coupling of N-Iminoquinolinium Ylides with Secondary Amines

作者：Hua, Zerui[1,2];Fang, Lei[1,2];Wu, Shengying[1,2];Wang, Limin[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2016

卷号：2016

期号：29

起止页码：4953

外文期刊名：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000386920600003)，CCR-EXPANDED(收录号:WOS:000386920600003)】；

基金：This research was financially supported by the National Nature Science Foundation of China (grant numbers 21272069, 20672035), the Fundamental Research Funds for the Central Universities, and Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.

语种：英文

外文关键词：Amination; Copper; Nitrogen heterocycles; Regioselectivity; Ylides

摘要：The copper-catalyzed cross-dehydrogenative coupling of N-iminoquinolinium ylides with secondary amines led to ortho-amino-substituted quinoline derivatives with high levels of regioselectivity in good yields. This direct C-H bond amination transformation employs CuI as the catalyst without the use of a ligand, external oxidant, or base. The reaction is operationally simple and can be conducted under mild conditions. The N-benzoyl directing group can be removed without any additional steps.