文献类型：期刊文献

英文题名：Iron Homeostasis Regulating Glycopeptide Hydrogel Reprograms the Healing Process of Diabetic Wounds Infected With MRSA

作者：Liu, Shangpeng[1];Ge, Zhenghong[1];Liu, Yaping[1];Chen, Ran[1];Xu, Jiaxi[1];Zhou, Yuxiao[2];Sun, Min[2,3];Fan, Zhen[1,2];Du, Jianzhong[1,2,3]

机构：[1]Tongji Univ, Sch Mat Sci & Engn, Dept Polymer Mat, Shanghai 201804, Peoples R China;[2]Tongji Univ, Clin Res Ctr Anesthesiol & Perioperat Med, Dept Gynaecol & Obstet, Shanghai Peoples Hosp 4,Sch Med,Translat Res Inst, Shanghai 200434, Peoples R China;[3]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2025

卷号：35

期号：51

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20252718712298);WOS:【SCI-EXPANDED(收录号:WOS:001519970100001)】；

基金：This research was supported by National Natural Science Foundation of China (52222306, 22335005, 22475154, and 22305177), international scientific collaboration fund of Science and Technology Commission of Shanghai Municipality (23520710900), Innovation Program of Shanghai Municipal Education Commission (2023ZKZD28), Shanghai Rising-Star Program (Sailing, 23YF1433000), and the Fundamental Research Funds for the Central Universities. Dr. Erik Jan Cornel (Ph.D. in chemistry, University of Sheffield, United Kingdom) helped to review and revise the entire paper.

语种：英文

外文关键词：diabetic wound; drug-resistance bacteria; peptide; programmable therapy; self-assembly

摘要：Optimal healing of diabetic chronic wound requires a well-organized cascade integration of bacterial death, cell migration and proliferation, and extracellular remodeling. However, such biological progress is usually impaired in chronic diabetic wound and traditional antibacterial hydrogels unmatched for ordered repair needs. Herein, an iron-coordinated glycopeptide hydrogel (Fe-GP gel) that could effectively treat MRSA-infected chronic diabetic wounds within 11 days by reprogramming healing process is developed. This Fe-GP hydrogel is formed based on glucomannan-decorated peptide nanofibers framework and then loaded with tannic acid/Fe nanocomplexes. The burst release of nanocomplexes is achieved to conduct the first healing stage, which could induce the ferroptosis-like death of methicillin-resistant Staphylococcus aureus (MRSA) for eliminating over 98% of MRSA bacteria by metabolism disrupting within 6 h. In the second healing stage, sustained release of glucomannan promotes M2 macrophage polarization (five times higher than control group) through extracellular signal-regulated kinase and signal transducer and activator of transcription 6 (ERK/STAT6) pathway within 2 days. After the elimination of MRSA and restoration of immune microenvironment, the remaining 3D peptide nanofibers framework is able to facilitate extracellular remodeling through anchoring fibroblast cells as the third healing stage within weeks. Overall, this glycopeptide hydrogel has demonstrated a promising approach to realize the orderly progression during healing process for enhanced treatment of drug-resistant bacteria-infected chronic wounds.