文献类型：期刊文献

英文题名：Incorporating zinc coordination driven nanozyme into chitosan and hyaluronic acid based nanoplatform for scavenging H2S/ROS in managing inflammatory bowel disease

作者：Zou, Jiafeng[1];Ding, Wenxing[1];Chen, You[1];Pan, Xier[1];Fu, Xiuzhi[1];Zheng, Shulei[1];Lin, Yiting[1];Xia, Chuanhe[1];Ma, Ying[1];Zhang, Xiaochun[2];Wu, Shuang[2];Gao, Feng[1,3,4,5]

机构：[1]East China Univ Sci & Technol, Shanghai Frontier Sci Ctr Optogenet Tech Cell Meta, Sch Pharm, Shanghai 200237, Peoples R China;[2]Yangzhou Univ, Clin Tradit Chinese Med Coll, Yangzhou 225001, Jiangsu, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Optogenet & Synthet Biol Interdisciplinary Res Ctr, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[5]East China Univ Sci & Technol, Sch Pharm, Pharmaceut Engn & Proc Chem Engn Res Ctr, Minist Educ,Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2025

卷号：361

外文期刊名：CARBOHYDRATE POLYMERS

收录：;EI(收录号：20251718305230);WOS:【SCI-EXPANDED(收录号:WOS:001482111500001)】；

基金：This work was financially supported by Development Program of China (grant 2019YFA0904800) ; National Natural Science Foundation of China (grant 32150030, 32030065, 32121005, and 92049304) ; Science and Technology Commission of Shanghai Municipality (grant 10DZ2220500) ; Shanghai Committee of Science and Technology (grant 11DZ2260600) ; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism. Research Unit of New Techniques for Live-cell Metabolic Imaging (Chinese Academy of Medical Sciences, grant 2019-I2M-5-013) . We thank the exceptional experimental environment of the State Key Laboratory of Bioreactor Engineering (Shanghai) , the Fundamental Research Funds for the Central Universities, the innovative research team of high-level local universities in Shanghai. We also thank Prof. Yuzheng Zhao (Y.Z., ECUST) and Prof. Minbo Lan (M.L., ECUST) for his help and financially support.

语种：英文

外文关键词：Nanozyme; Reactive oxygen species; Hydrogen sulfide; Chitosan; Hyaluronic acid; Inflammatory bowel disease

摘要：Inflammatory bowel disease (IBD) causes damage to patients, and therapy remains a crucial challenge owing to the presence of excessive reactive oxygen species (ROS) and hydrogen sulfide (H2S) in colonic inflammatory circulation. Herein, we report a shikonin (SK) and zinc (Zn) driven coordination nanozyme (SK-Zn, S-Z), which effectively scavenged ROS and H2S. Furthermore, a pH responsive targeted polymer nanoplatform (S-Z@ChF), consisting of S-Z, chitosan, hyaluronic acid and poly ferulic acid, was developed for the oral treatment of colitis. In vivo experiments revealed that the nanoplatform could target colonic inflammatory lesions, relieve inflammatory index and restore the colonic mechanical barrier. The transcriptomics and pharmacodynamic mechanism analysis revealed that S-Z@ChF scavenged ROS, inhibited nuclear factor kappa-B (NF-kappa B) and pyruvate kinase isozyme type M2 (PKM2) and signal transducer and activator of transcription 3 (STAT3) pathways, balancing the level of macrophage polarization and pro-inflammatory enzyme. Additionally, S-Z@ChF reliably regulated the gut microbiota during H2S scavenging. In conclusion, S-Z@ChF, which provides multiple anti-inflammatory pathways and microenvironment reprogramming support for blocking inflammatory circulation, was found to be biologically safe, with significant potential for clinical application in IBD.