文献类型：期刊文献

英文题名：Eutectogel based on multi-functional deep eutectic solvent for acne infection treatment

作者：Yang, Qinghua[1];Liu, Zhuoni[1];Yin, Tianxiang[1];Wang, Xiaoyong[1];Yuan, Jing[2,3]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Sch Med, Shanghai 200233, Peoples R China;[3]Shanghai Univ Med & Hlth Sci, Shanghai Peoples Hosp East 6, Shanghai 201306, Peoples R China

年份：2024

卷号：101

外文期刊名：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001335805100001)】；

基金：This work was supported by the National Natural Science Foundation of China (Projects 21773063, 22273022) , and Scientific Research Foundation of SUMHS (SSF-23-14-003) .

语种：英文

外文关键词：Matrine; Lauric acid; Curcumin; Transdermal delivey

摘要：Deep eutectic solvents (DESs), as a new type of green and easily designable solvent, showed great potential applications in various fields. In this work, a novel deep eutectic solvent based on active pharmaceutical ingredient matrine and lauric acid was developed. The structure, thermal stability, and cytotoxicity were investigated by various technologies. The prepared DES displayed excellent ability on enhancing the solubility of curcumin, and the curcuim showed high stability in DES. Moreover, DES as well as curcumin-contained DES possessed good antioxidant and anti-P. acne activity. More importantly, the prepared DES can act as a gelator to form eutectogel in water, which was confirmed from the rheological behavior and scanning electron microscope (SEM) measurement. The curcumin-contained eutectogel displayed good injectable and permeation ability. Therefore, the prepared multi-functional DES (i.e. antioxidant, antibacterial agent, solvent and stabilizer of curcumin, and gelator) provides a new strategy to construct transdermal delivery system that displays potential application on treatment of acne infection.