文献类型：期刊文献

英文题名：Selenium-Containing Nano-Micelles Delay the Cellular Senescence of BMSCs Under Oxidative Environment and Maintain Their Regenerative Capacity

作者：He, Zirui[1,2];Xie, Fangru[2];Sun, Chuanhao[3];Wang, Xuan[1];Zhang, Fan[2];Zhang, Yan[3];Liu, Changsheng[1,2];Yuan, Yuan[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China

年份：2025

卷号：12

期号：9

外文期刊名：BIOENGINEERING-BASEL

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001580261000001)】；

基金：This research was funded by Program of Shanghai Academic/Technology Research Leader, grant number 22XD1433900; National Natural Science Foundation of China grant number No.32271401); National Key Research and Development Program of China, grant number 2022YFC2405702; the Basic Science Center Project of National Natural Science Foundation of China, grant number T2288102.

语种：英文

外文关键词：selenium-containing nano-micelles; reactive oxygen species; bone marrow mesenchymal stem cells; cellular senescence

摘要：The cellular senescence and functional decline of stem cells are primary contributors to the reduced regenerative capacity and weakened disease resistance in aged tissues. Among the various factors involved, oxidative stress resulting from the accumulation of reactive oxygen species (ROS) is a key driver of stem cell senescence. In an oxidative environment, cells continuously generate ROS, which accelerates cellular senescence and leads to functional deterioration. To intervene in the cellular senescence process of stem cells under such conditions, we selected bone marrow mesenchymal stem cells (BMSCs) as the model system and developed ROS-responsive selenium (Se)-containing nano-micelles capable of efficiently scavenging intracellular ROS. The optimal formulation was determined by modulating the selenium content. Analysis of cellular senescence markers and regenerative capacity reveals that nano-micelles containing 8% Se (Wt %), at a concentration of 15 mu g/mL, can significantly modulate ROS levels in BMSCs under oxidative stress, thereby effectively delaying cellular senescence and preserving the osteogenic differentiation potential of BMSCs. These findings offer a promising strategy for mitigating stem cell senescence.