文献类型：期刊文献

英文题名：Promoting implant osseointegration via the osteoblast-selective β-amino acid polymer strategy

作者：Chen, Qi[1];Gu, Jiawei[2];Zhang, Haodong[2];Zhang, Donghui[1,3];Wang, Yuwen[2];Liu, Guojian[2];Zhu, Xiang[2];Zhang, Xinyue[2];Cao, Chuntao[2];Yuan, Yuan[2];Liu, Runhui[1,2,4]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Engn Res Ctr Biomed Mat,Shanghai Frontiers Sci Ctr, Sch Mat Sci & Engn,Minist Educ,Key Lab Ultrafine M, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Biotechnol, Shanghai 200237, Peoples R China;[4]Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Suzhou 215163, Peoples R China

年份：2025

卷号：16

期号：1

外文期刊名：NATURE COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001545534800023)】；

基金：This research was supported by the National Natural Science Foundation of China (No. T2325010 (R.L.), 32301124 (Q.C.), 52361165622 (R.L.), and 22205063 (D.Z.)), Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission), Research Program of State Key Laboratory of Bioreactor Engineering. The authors also thank the Research Center of Analysis and Test of East China University of Science and Technology for the help with the characterization. We thank the staff members of the Integrated Laser Microscopy System at the National Facility for Protein Science in Shanghai (NFPS), Zhangjiang Lab, China for providing technical support and assistance in data collection.

语种：英文

摘要：Osseointegration for implants, especially bioinert implants, poses significant clinical challenges. Overcoming fibrotic encapsulation and promoting osseointegration at the implant interface are critical for successful bone repair, which highly expected biomaterials with osteoblast over fibroblast selectivity. However, few materials possess the function. beta-amino acid polymers have demonstrated cell adhesion property, easy preparation, and robust stability to resist proteolysis as emerging biomaterials. Here, we develop amphiphilic beta-amino acid polymers that demonstrate exceptional osteoblast vs fibroblast selectivity, outperforming the natural osteoblast-selective KRSR peptide. The optimal polymer selectively supports osteoblast adhesion by manipulating the adsorption of serum proteins and the presentation of RGD motifs on polymer-modified surfaces. In vivo study using polymer-modified titanium-implants in female rat maxillary bone reveals that the optimal polymer substantially promotes osseointegration of titanium-implants compared to uncoated titanium-implants, which tend to develop fibrous encapsulation. This study demonstrates the effectiveness of our strategy in designing osteoblast-selective biomaterials and implies the promising application of beta-amino acid polymer as emerging osteoblast-selective biomaterials to promote osseointegration.