文献类型：期刊文献

英文题名：ONE-POT SYNTHESIS OF 1H-BENZIMIDAZOLE DERIVATIVES USING THIAMINE HYDROCHLORIDE AS A REUSABLE ORGANOCATALYST

作者：Lei, Min;Ma, Lei[1,2];Hu, Lihong[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China

年份：2012

卷号：42

期号：20

起止页码：2981

外文期刊名：SYNTHETIC COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000305633500005)，CCR-EXPANDED(收录号:WOS:000305633500005)】；

基金：This work was supported by the Chinese National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program" (Grants 2009ZX09301-001, 2009ZX09102), the National Natural Science Foundation of China (Grants 90713046, 30772638, 30925040), and CAS Foundation (Grant KSCX2-YW-R-179).

语种：英文

外文关键词：Aldehyde; 1H-benzimidazole; green chemistry; o-phenylenediamine; thiamine hydrochloride (VB1)

摘要：A simple and efficient one-pot synthesis of 1H-benzimidazole derivatives using thiamine hydrochloride (VB1) as the organocatalyst from o-phenylenediamine and aldehyde in dimethylformamide is described. Compared to classical reaction conditions, this new method consistently has the advantages of excellent yields, metal-ion-free procedure, and good recovery and reusablity of catalyst.