文献类型：期刊文献

中文题名：Optical Resolution of DL-Tartaric Acid Mediated by Diastereomeric Salts Crystallization: A Useful Method for Exploring and Optimizing Experimental Conditions

英文题名：Optical Resolution of DL-Tartaric Acid Mediated by Diastereomeric Salts Crystallization: A Useful Method for Exploring and Optimizing Experimental Conditions

作者：LolaKokila[1];蔡水洪[1];陈孔常[1]

机构：[1]Department of Chemical Engineering, Thermodynamics Research Center, East China University of Science & Tech-nology, Shanghai 200237, China

年份：2002

卷号：10

期号：2

起止页码：244

中文期刊名：Chinese Journal of Chemical Engineering

外文期刊名：中国化学工程学报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：resolution; optimization; central composite rotatable design; modeling

外文关键词：光学离析;旋光拆开;DL-酒石酸;非对映盐类结晶化;最佳试验条件

摘要：A response surface modeling approach for simultaneous optimization of optical purity and yield was applied to the resolution of tartaric acid to study the effects of both the amount of the solvent and the amount of the resolving agent a-methylbenzyl amine on the resolution results. The direction of changing the experimental conditions was determined from the initial response study, and expected high yield of the pure L(+)-tartaric acid-L(-)-a-methylbenzyl amine salt was obtained.
A response surface modeling approach for simultaneous optimization of optical purity and yield wasapplied to the resolution of tartaric acid to study the effects of both the amount of the solvent and the amountof the resolving agent α-methylbenzyl amine on the resolution results. The direction of changing the experimen-tal conditions was determined from the initial response study, and expected high yield of the pure L(+)-tartaricacid-L(-)-α-methylbenzyl amine salt was obtained.