文献类型：会议论文

英文题名：Nano-sized spherical polyelectrolyte brushes: Potential protein carriers and diagnostic tools

作者：Wang, Xiang[1]; Xu, Jun[1]; Li, Li[1]; Guo, Xuhong[1]; Junge, Catrin[2]

机构：[1] State-Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai, 200237, China; [2] Chemical Engineering, University of Applied Science, 23562,Luebeck, Germany

会议论文集：2nd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2008

会议日期：May 16, 2008 - May 18, 2008

会议地点：Shanghai, China

语种：英文

外文关键词：Emulsification - Polyethylenes - Emulsion polymerization - Hydrogels - Polyelectrolytes - Spheres - Biocompatibility - Proteins - Diagnosis

摘要：By using a novel method of thermo-controlled emulsion polymerization, we prepared biocompatible nano-sized spherical polyelectrolyte brushes which consist of a solid polymer core and a poly(acrylic acid) (PAA) shell covalently attached on the core surface densely by one end. Dynamic light scattering (DLS) was employed to determine the size of the brushes and to monitor the brush growing during the preparation. The size of the brush is tunable by controlling pH and salt concentration in the solution while the pH and salt concentration inside the brush keep constant due to the polyelectrolyte Donnan effect. These nano-sized spherical polyelectrolyte brushes should be ideal candidates for protein carriers and diagnostic tools after attaching diagnostic groups inside the brushes. ? 2008 IEEE.