文献类型：期刊文献

英文题名：Toxicological effect of MPA-CdSe QDs exposure on zebrafish embryo and larvae

作者：Zhang, Wei[1,2,3];Lin, Kuangfei[1,2,3];Sun, Xue[1,2,3];Dong, Qiaoxiang[4];Huang, Changjiang[4];Wang, Huili[4];Guo, Meijin[5];Cui, Xinhong[6]

机构：[1]E China Univ Sci & Technol, State Environm Protect Key Lab Environm Risk Asse, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Sch Resource & Environm Engn, Shanghai 200237, Peoples R China;[4]Wenzhou Med Coll, Zhejiang Prov Key Lab Technol & Applicat Model Or, Wenzhou 325035, Peoples R China;[5]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[6]Shanghai Inst Landscape Gardening, Shanghai 200233, Peoples R China

年份：2012

卷号：89

期号：1

起止页码：52

外文期刊名：CHEMOSPHERE

收录：;EI(收录号：20122815245062);WOS:【SCI-EXPANDED(收录号:WOS:000307158600007)】；

基金：This research was financially supported by the National Natural Science Foundation of China (40901148, 40871223), the Major State Basic Research Development Program of China (2011CB200904), the Scientific Project on Treatment and Control of Water Pollution (2012ZX07115), the National Forestry Public Welfare Science and Technology Research Program of China (201104088), the Fundamental Research Funds for the Central Universities (WB0911011), the Natural Science Foundation of Shanghai (11ZR1409400), and Zhejiang Provincial Science Foundation of China (Y5100333). We also would like to thank the anonymous referees for their helpful comments on this paper.

语种：英文

外文关键词：MPA-CdSe QDs; Zebrafish embryo; Zebrafish larvae; Developmental toxicity; Behavioral toxicity

摘要：Cadmium selenium (CdSe) quantum dots (QDs) are semiconductor nanocrystals that hold wide range of applications and substantial production volumes. Due to unique composition and nanoscale properties, their potential toxicity to aquatic organisms has increasingly gained a great amount of interest. However, the impact of CdSe QDs exposure on zebrafish embryo and larvae remains almost unknown. Therefore, the lab study was performed to determine the developmental and behavioral toxicities to zebrafish under continuous exposure to low level CdSe QDs (0.05-31.25 mg L-1) coated with mercaptopropionic acid (MPA). The results showed MPA-CdSe exposure from embryo to larvae stage affected overall fitness. Our findings for the first time revealed that: (1) The 120 h LC50 of MPA-CdSe for zebrafish was 1.98 mg L-1; (2) embryos exposed to MPA-CdSe resulted in malformations incidence and lower hatch rate; (3) abnormal vascular of FLI-1 transgenic zebrafish larvae appeared after exposure to MPA-CdSe including vascular junction, bifurcation, crossing and particle appearance; (4) larvae behavior assessment showed during MPA-CdSe exposure a rapid transition from light-to-dark elicited a similar, brief burst and a higher basal swimming rate; (5) MPA-CdSe induced embryos cell apoptosis in the head and tail region. Results of the observations provide a basic understanding of MPA-CdSe toxicity to aquatic organisms and suggest the need for additional research to identify the toxicological mechanism. (c) 2012 Elsevier Ltd. All rights reserved.