文献类型：期刊文献

中文题名：NIR-absorbing superoxide radical and hyperthermia photogenerator via twisted donor-acceptor-donor molecular rotation for hypoxic tumor eradication

英文题名：具有扭曲D-A-D转子结构的近红外光疗试剂能够同时产生超氧自由基和光热用于消除乏氧肿瘤

作者：Yucheng Zhu[1];Qinghua Wu[2];Chao Chen[1];Guoliang Yang[1];Hongliang Cao[1];Yun Gao[1];Lijuan Jiao[2];Erhong Hao[2];Weian Zhang[1]

机构：[1]Shanghai Key Laboratory of Functional Materials Chemistry,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China;[2]Laboratory of Functional Molecular Solids,Ministry of Education,Anhui Laboratory of Molecule Based Materials(State Key Laboratory Cultivation Base)and School of Chemistry and Materials Science,Anhui Normal University,Wuhu 241000,China

年份：2021

卷号：64

期号：12

起止页码：3101

中文期刊名：Science China Materials

外文期刊名：中国科学(材料科学(英文版)

收录：CSTPCD;;Scopus;CSCD:【CSCD2021_2022】；PubMed;

基金：This work was supported by the National Natural Science Foundation of China (21875063 and 21871006), the Science and Technology Commission of Shanghai Municipality for Shanghai International Cooperation Program (19440710600), and the Open Funding Project of the State Key Laboratory of Bioreactor Engineering.

语种：英文

中文关键词：tumor hypoxia;superoxide radical;hyperthermia;D-A-D structure;molecular rotation

外文关键词：肿瘤治疗;抗肿瘤实验;超氧自由基;光动力治疗;乏氧;近红外吸收;光声成像;屏蔽效应;

摘要：Hypoxia severely impedes the therapeutic efficacies of tumor chemotherapy,radiotherapy and conventional photodynamic therapy(typeⅡPDT).Herein,we proposed a nonplanar near-infrared(NIR)-absorbing hyperthermia and superoxide radical(O^(-)_(2))photogenerator(TB)against hypoxic tumors.TB particularly possessed a favorable O^(-)_(2)generation capability under 808 nm laser irradiation with the donoracceptor-donor(D-A-D)molecular structure.Moreover,owing to molecular rotation,potent hyperthermia was realized under continuous laser irradiation.For the usage of hypoxic tumor treatment,TB was encapsulated by a block copolymer,poly(ethylene glycol)-b-poly(latic acid)(PEG_(45)-b-PLA_(24)),to fabricate phototheranostic nanoparticles(TB NPs).Due to the twisted molecular structure and the shielding effect of long alkyl chains,theπ-πstacking-induced quenching of O^(-)_(2)could be reduced after the fabrication of nano-assemblies.Significantly,TB NPs exhibited satisfactory O^(-)_(2)generation for type I PDT and a simultaneously distinct photothermal conversion efficiency(PCE,62%)for photothermal therapy(PTT)to combat hypoxic tumor cells.Moreover,the high PCE endowed TB NPs with high-performance photoacoustic(PA)and photothermal imaging capability.In vivo experiments demonstrated that TB NPs possessed an outstanding phototherapeutic efficacy for eradicating hypoxic tumors.This study established a novel approach for constructing oxygenindependent phototherapeutic reagent against hypoxic tumors.
肿瘤乏氧微环境严重抑制了肿瘤化疗、放疗及Ⅱ型光动力治疗的疗效.因此,开发非氧气依赖性的肿瘤治疗方式具有重要意义.在此,我们设计了一种超稳定的近红外吸收的光热和超氧自由基(O^(-)_(2)·)供体(TB).由于D-A-D分子结构,在808 nm激光照射下,TB能够产生大量O^(-)_(2)·.此外,由于电子供体同时还充当了转子基元,TB还能够在连续激光照射下产生极强的光热.为了将TB应用于乏氧肿瘤治疗,TB被嵌段共聚物PEG_(45)-b-PLA_(24)封装以制成纳米颗粒(TB NPs).扭曲的分子结构和长烷基链的屏蔽效应有效降低了组装体由于聚集所导致的O^(-)_(2)·淬灭.组装而成的TB NPs仍具有令人满意的O^(-)_(2)·生成能力和较高的光热转化效率,因而TB NPs可被用于乏氧肿瘤治疗.此外,由于TB NPs的光热转换效率较高,其可被用于光声成像和光热成像.在活体抗肿瘤实验中,通过连续光照,TB NPs可以完全消除乏氧肿瘤.本研究为设计非氧依赖性的光疗试剂用于乏氧肿瘤治疗提供了一种全新的策略.