文献类型：期刊文献

英文题名：Effects of different sulfonation times and post-treatment methods on the characterization and cytocompatibility of sulfonated PEEK

作者：Ma, Rui[1];Wang, Jialin[1];Li, Chengxin[2];Ma, Kai[2];Wei, Jie[3];Yang, Pei[1];Guo, Dagang[2];Wang, Kunzheng[1];Wang, Wei[1]

机构：[1]Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Bone & Joint Surg, 157 Xiwu Rd, Xian 710004, Shaanxi, Peoples R China;[2]Xi An Jiao Tong Univ, Sch Mat Sci & Engn, State Key Lab Mech Behav Mat, Xian, Peoples R China;[3]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai, Peoples R China

年份：2020

卷号：35

期号：3

起止页码：342

外文期刊名：JOURNAL OF BIOMATERIALS APPLICATIONS

收录：;EI(收录号：20202508850036);WOS:【SCI-EXPANDED(收录号:WOS:000542422300001)】；

基金：The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was financially supported by the National Natural Science Foundation of China (No. 81702130), Natural Science Foundation of Shaanxi Province (No. 2019JQ-143) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Polyetheretherketone; PEEK; sulfonation; surface modification; sulfuric acid

摘要：Polyetheretherketone (PEEK) has been becoming a popular implant material in orthopaedic applications. The lack of bioactivity affects PEEK's long-term lifetime, and appropriate surface modification is an effective way to enhance its bioactivity. Sulfonation of PEEK can endow PEEK with a 3 D porous network surface and improve its bioactivity. This study is aimed at exploring an optimal sulfonation time and a post-treatment method of PEEK sulfonation. PEEK was immersed into concentrated sulfuric acid for different sulfonation times and experienced different post-treatment methods to turn into sulfonated PEEK (SPEEK). The immersion times were 0.5 min (SPEEK0.5), 1 min (SPEEK1), 3 min (SPEEK3), 5 min (SPEEK5) and 7 min (SPEEK7), and the post-treatment methods were acetone rinsing (SPEEK-T1), hydrothermal treatment (SPEEK-T2) and NaOH immersion (SPEEK-T3). Scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy, hydrophilic property, ion release and cell viability evaluations were performed to optimize the sulfonation time, and the SEM, EDS, ion release and cell viability were analysed to optimize the post-treatment method. The results showed a porous network structure was formed on all samples of SPEEK, and the porous structure became more obvious and the S concentration increased with increasing sulfonation time. However, too long of an immersion time (SPEEK7) tended to damage the superficial porous structure and left a higher content of sulfuric acid, which could inhibit the growth of MC3T3E1 cells on its surface. In addition, the surface morphology, residual sulfuric acid and cytocompatibility of SPEEK-T1, SPEEK-T2 and SPEEK-T3 were not distinctly different. In conclusion, a 5-min sulfonation time was considered to be the optimal selection, and acetone rinsing, hydrothermal treatment and NaOH immersion showed the same effect in removing the residual sulfuric acid. The understanding of optimal sulfonation time and post-treatment method can provide a theoretical basis in preparing SPEEK for orthopaedic applications.