文献类型：期刊文献

英文题名：Highly Efficient Construction of Trifluoromethylated Heterocycles; [3+2] Annulation of N,N′-Cyclic or C,N-Cyclic Azomethine Imines with Trifluoromethyl-Containing Electron-Deficient Olefins

作者：Wang, De[1,2];Deng, Hong-Ping[3];Wei, Yin[3];Xu, Qin[1,2];Shi, Min[1,2,3]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

年份：2013

卷号：2013

期号：2

起止页码：401

外文期刊名：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000316190700019)，CCR-EXPANDED(收录号:WOS:000316190700019)】；

基金：We thank the Shanghai Municipal Committee of Science and Technology (grant number 11JC1402600), the National Basic Research Program of China, (973)-2009CB825300, the Fundamental Research Funds for the Central Universities, and the National Natural Science Foundation of China (NSFC) for financial support (grant numbers 21072206, 20472096, 20872162, 20672127, 21121062, and 20732008).

语种：英文

外文关键词：Synthetic methods; Nitrogen heterocycles; Fluorine; Diastereoselectivity; Annulation

摘要：A highly regio- and stereoselective synthesis of pyrazolidine analogues by the use of N,N'-cyclic or C,N-cyclic azomethine imines with two different trifluoromethyl-containing olefins has been developed. The method affords highly functionalized trifluoromethyl-containing pyrazolidine analogues in excellent yields with high diastereoselectivities under mild conditions.