文献类型：期刊文献

英文题名：Curdepsidones B-G, Six Depsidones with Anti-Inflammatory Activities from the Marine-Derived Fungus Curvularia sp. IFB-Z10

作者：Ding, Yi[1];An, Faliang[1];Zhu, Xiaojing[1];Yu, Haiyuan[1];Hao, Liling[1];Lu, Yanhua[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Mei Long Rd, Shanghai 200237, Peoples R China

年份：2019

卷号：17

期号：5

外文期刊名：MARINE DRUGS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000470964600019)】；

基金：This research was funded by the National Natural Science Foundation of China (41876189, 81703388), the National Key R&D Program of China (2018YFC1706200), the 111 Project (B18022), and the Fundamental Research Funds for the Central Universities (22221818014, 222201714023).

语种：英文

外文关键词：marine-derived fungus; Curvularia sp; IFB-Z10; depsidones; ECD calculation; anti-inflammatory activity; Propionibacterium acnes

摘要：Six new depsidones, curdepsidones B-G (1-6), were obtained from the marine-derived fungus Curvularia sp. IFB-Z10. Their planar structures were determined by comprehensive analysis of HRESIMS and 1D/2D-NMR data. The absolute configuration of curdepsidones B-C (1-2) were established by synergistic use of DFT/NMR (density functional theory/nuclear magnetic resonance) and TDDFT/ECD (time-dependent density functional theory/electronic circular dichroism) calculations. Partial isolated compounds were tested for their anti-inflammatory activities in Propionibacterium acnes-induced THP-1 cells. Curdepsidone C (2) displayed significant anti-inflammatory properties with an IC50 value of 7.47 +/- 0.35 M, and reduced the P. acnes-induced phosphorylation levels of JNK and ERK in a dose-dependent mechanism. The possible anti-inflammatory mechanism of 2 was also investigated by molecular docking.