文献类型：期刊文献

英文题名：Molecular imprinted macroporous chitosan coated mesoporous silica xerogels for hemorrhage control

作者：Dai, Chenglong[1,2,3];Liu, Changsheng[1,2,3];Wei, Jie[1,2,3];Hong, Hua[1,2,3];Zhao, Qinghui[1,2,3]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China

年份：2010

卷号：31

期号：30

起止页码：7620

外文期刊名：BIOMATERIALS

收录：;EI(收录号：20103413173720);WOS:【SCI-EXPANDED(收录号:WOS:000281498600003)】；

基金：The authors are indebted to the financial support from the Major Program of National Natural Science Foundation of China (No. 50732002) and Program for Changjiang Scholars and Innovative Research Team in University.

语种：英文

外文关键词：Chitosan; Silica xerogel; Molecular imprinting; Hemorrhage control; Biocompatibility

摘要：Efficacious hemostatic agents have significant potential for use in rapid exsanguinating hemorrhage control by emergency medical technician or military medic nowadays. Unfortunately, the topical hemostats currently available in market still have various disadvantages. In this study, a series of macroporous chitosan coated mesoporous silica xerogel beads (CSSX) with good biocompatibility were developed. They consisted of mesoporous silica xerogel cores and chitosan layers with macroporous structure by using modified sol-gel process and PEG molecular imprinting technique. The textural properties of the CSSX beads were optimized by in vitro and in vivo evaluation for promoting blood clotting and the results indicated that the prepared CSSX beads can significantly accelerate the contact activation pathway of coagulation cascade and produce desirable hemostasis, with the best efficiency from the CSSX prepared with 2% chitosan and 5% PEG. Furthermore, these CSSX beads were observed to create no exothermic reaction and the subsequential tissue thermal injury by histological examination, and exhibited no obvious cytotoxicity even after 7 days. The results of the present study forward CSSX bead as a safe hemostatic system and present a platform for further optimization studies of materials with enhanced hemostatic capabilities for specific injury types. (C) 2010 Elsevier Ltd. All rights reserved.