文献类型：期刊文献

英文题名：Advance in Hybrid Peptides Synthesis

作者：Zou, Jingcheng[1];Zhou, Min[1];Xiao, Ximian[2];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Res Ctr Biomed Mat, Sch Mat Sci & Engn,Minist Educ, Frontiers Sci Ctr Materiobiol & Dynam Chem,Key La, Shanghai 200237, Peoples R China

年份：2022

卷号：43

期号：23

外文期刊名：MACROMOLECULAR RAPID COMMUNICATIONS

收录：;EI(收录号：20223412602436);WOS:【SCI-EXPANDED(收录号:WOS:000842360300001)】；

基金：J.Z. andM.Z. contributed equally to thiswork. This research was supported by the National Natural Science Foundation of China (Nos. 22075078 and 21861162010), Free exploring basic research project at Shenzhen Research Institute of ECUST (2021Szvup042), Program of Shanghai Academic/Technology Research Leader (20XD1421400), China National Postdoctoral Program for Innovative Talents (BX2021102), and China Postdoctoral Science Foundation (2022M710050).

语种：英文

外文关键词：hybrid peptides; alpha/beta-peptides; peptide/peptoid hybrids; polymerization; solid-phase synthesis

摘要：Hybrid peptides with heterogeneous backbone are a class of peptide mimics with adjustable proteolytic stability obtained from incorporating unnatural amino acid residues into peptide backbone. alpha/beta-peptides and peptide/peptoid hybrids are two types of hybrid peptides that are widely studied for diverse applications, and several synthetic methods have been developed. In this mini review, the advance in hybrid peptide synthesis is summarized, including solution-phase method, solid-phase method, and novel polymerization method. Conventional solution-phase method and solid-phase method generally result in oligomers with defined sequences, while polymerization methods have advantages in preparing peptide hybrid polymers with high molecular weight with simple operation and low cost. In addition, the future development of polymerization method to realize the control of the peptide hybrid polymer sequence is discussed.