文献类型：期刊文献

英文题名：Hierarchical Dendritic Mesoporous TiO2 Nanocomposites for Highly Selective Enrichment of Endogenous Phosphopeptides

作者：Pu, Chenlu[1];Zhao, Hongli[1];Hong, Yayun[1];Wang, Zhenxing[1];Zheng, Yu[1];Lan, Minbo[1,2]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Res Ctr Anal & Tes, Shanghai 200237, Peoples R China

年份：2021

卷号：9

期号：17

起止页码：5818

外文期刊名：ACS SUSTAINABLE CHEMISTRY & ENGINEERING

收录：;EI(收录号：20211910309498);WOS:【SCI-EXPANDED(收录号:WOS:000648430000006)】；

基金：The financial supports from the Fundamental Research Funds for the Central Universities (no. 50321102017022), the Natural Science Foundation of Shanghai (19ZR1412000), and the Science and Technology Commission of Shanghai Municipality (STCSM, no. 20520712500) are acknowledged. The authors are thankful for the help in mass spectrometry analysis from the Research Center of Analysis and Test of the East China University of Science and Technology.

语种：英文

外文关键词：oriented growth; hierarchically porous; titanium dioxide; nanostructures; phosphopeptide enrichment

摘要：The uniform growth of metal oxides into mesoporous nanostructures with controllable orientations is challenging but of significance. Here, a polydopamine (PDA)induced oriented growth strategy is proposed to uniformly grow metal ions into mesoporous metal oxides with controllable orientation. Two mesoporous nanostructures (3D hierarchical dendritic nanostructures and 2D nanosheets) were constructed by this strategy. It is worth emphasizing that the 3D hierarchical mesoporous nanostructures (DMSNs@TiO2) are formed by constructing single-layered porous TiO2 in dendritic mesoporous tunnels, which is different from the previously reported generation of hierarchical pores inside frameworks or accumulation of various channels. In such a pore system, small pores are connected by large pores, thereby enhancing the accessibility of pores. DMSNs@TiO2 with a large surface area and connected hierarchical pore structure exhibit highly improved phosphopeptide enrichment performance compared with commercial TiO2 and single-pored TiO2. Especially for real samples such as human saliva, DMSNs@TiO2 captured 49 endogenous phosphopeptides from 1 mu L of saliva, demonstrating their broad prospects in phosphopeptidomics analysis.