文献类型：期刊文献

英文题名：Copper-Catalyzed Coupling Cyclization of gem-Difluoroalkenes with Activated Methylene Carbonyl Compounds: Facile Domino Access to Polysubstituted Furans

作者：Zhang, Xuxue[1];Dai, Wenpeng[1];Wu, Wei[1];Cao, Song[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2015

卷号：17

期号：11

起止页码：2708

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000355962200037)，CCR-EXPANDED(收录号:WOS:000355962200037)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (Grant Nos. 21472043 and 21272070), and the Key Project in the National Science & Technology Pillar Program of China in the twelfth five-year plan period (2011BAE06B01-15).

语种：英文

摘要：A novel and efficient CuI-catalyzed synthesis of 2,3,5-trisubstituted furans was developed via coupling cyclization of gem-difluoroalkenes with active methylene carbonyl compounds such as 1,3-dicarbonyl compounds, acetoacetonitrile, and phenylsulfonylacetone with the assistance of a base. Commercial availability of substrates or reagents, good to high isolated yields, and excellent functional group compatibility make this transformation a powerful tool for the synthesis of various furans. A plausible mechanism involving the allenyl ketone is suggested.