文献类型：期刊文献

中文题名：药用植物萜类化合物的生物合成与代谢调控研究进展

英文题名：Research progress in terms of the biosynthesis and regulation of terpenoids from medicinal plants

作者：时敏[1,2];王瑶[2];周伟[2];花强[1];开国银[2]

机构：[1]华东理工大学生物反应器工程国家重点实验室,上海200237;[2]上海师范大学生命与环境科学学院,上海200234

年份：2018

卷号：48

期号：4

起止页码：352

中文期刊名：中国科学：生命科学

外文期刊名：Scientia Sinica(Vitae)

收录：CSTPCD;;北大核心:【北大核心2017】；CSCD:【CSCD2017_2018】；PubMed;

基金：国家自然科学基金(批准号:81522049;31270007;31571735;30900110);上海市科委项目(批准号:17JC1404300;15430502700);上海市曙光学者计划(批准号:16SG38)资助

语种：中文

中文关键词：药用植物;萜类化合物;次级代谢;生物合成;调控

外文关键词：medicinal plants, terpenoids, secondary metabolism, biosynthesis, regulation

摘要：药用植物来源的萜类化合物是自然界中广泛存在的次级代谢产物,其结构与功能多样,具有抗癌、抗氧化、抗病毒等广泛的药理作用.本文以青蒿素、丹参酮、人参皂苷为例,总结了其代谢途径关键酶基因、转录调控、代谢工程、合成生物学、合成与转运等研究进展,并对今后的发展方向进行展望.
Terpenoids from medicinal plants are widespread secondary metabolites in nature and exist as multiple types with different structures that are crucial in plant growth and development. Moreover, terpenoids exert a broad range of biological activities, including antitumor, antioxidation, anti-viral, and so on. In this study, artemisinin, tanshinone, and ginsenoside were selected as three representative examples, and progress in terms of research on biosynthetic genes, transcriptional regulation, metabolic engineering, synthetic biology, biosynthesis and transport was summarized. Future prospects including functional genes excavation and regulation mechanism network of terpenoids were also discussed.