文献类型：期刊文献

英文题名：Catalytic asymmetric Michael addition of α,β-unsaturated aldehydes to Ni(II) complexes of the Schiff base of glycine

作者：Luo, Xiaoyan[1];Jin, Zhichao[1];Li, Pengfei[1];Gao, Jiabin[1];Yue, Weimin[1];Liang, Xinmiao[1];Ye, Jinxing[1]

机构：[1]E China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Sch Pharm, Shanghai 200237, Peoples R China

年份：2011

卷号：9

期号：3

起止页码：793

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20110513631455);WOS:【SCI-EXPANDED(收录号:WOS:000286431500028)，CCR-EXPANDED(收录号:WOS:000286431500028)】；

基金：We are grateful for the financial support from National Natural Science Foundation of China (20902018), Shanghai Pujiang Program (08PJ1403300) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Addition reactions - Nickel compounds - Aldehydes

摘要：The conjugate addition of Ni(II) complexes of glycine Schiff base to alpha,beta-unsaturated aldehydes catalyzed by (S)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine afforded adducts in excellent yields with up to 49 : 1 dr and 95% ee. This method enables the construction of two adjacent chiral centers in one step, and offers an alternative route to chiral alpha-amino acid derivatives.