文献类型：期刊文献

英文题名：3(2H)-pyridazinone derivatives: a new scaffold for novel plant activators

作者：Shi, Qinjie[1];Shi, Yanxia[2];Chang, Kang[1];Chen, Jianqin[1];Zhao, Zhenjiang[3];Zhu, Weiping[1];Xu, Yufang[1];Li, BaoJu[2];Qian, Xuhong[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100081, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2019

卷号：9

期号：62

起止页码：36204

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20194707705926);WOS:【SCI-EXPANDED(收录号:WOS:000497825500033)】；

基金：This work was financially supported by the National Research and Development Program of China (2018YFD0200100), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Electric resistance - Fungicides - Scaffolds

摘要：Due to the emergence of drug resistance, pesticide residue and environmental contamination, it is important to develop novel eco-friendly strategies to protect plants. Among them, plant activators have been gaining more and more attention. Herein, based on SHAFTS method, a new scaffold for novel plant activators was predicted and the discovery and structure-activity relationships of a series of 3(2H)-pyridazinone derivatives as novel plant activators were elucidated in detail. The vast majority of compounds exhibited excellent broad-spectrum induced resistance activity against tested diseases in vivo but no direct antimicrobial activity in vitro. Among them, compound 32 showed excellent efficacy against four pathogens and great potential as new plant activators in crop protection.