文献类型：期刊文献

英文题名：Cobalt-Catalyzed Ortho-C(sp2)-H Amidation of Benzaldehydes with Dioxazolones Using Transient Directing Groups

作者：Huang, Jie[1];Ding, Jun[2,3];Ding, Tong-Mei[2,3];Zhang, Shuiyi[1];Wang, Yaqiu[1];Sha, Feng[1];Zhang, Shu-Yu[2,3];Wu, Xin-Yan[1];Li, Qiong[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China

年份：2019

卷号：21

期号：18

起止页码：7342

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000487577200033)，CCR-EXPANDED(收录号:WOS:000487577200033)】；

基金：This work was supported by the Fundamental Research Funds for the Central Universities (222201814019, 201910251027), NSFC (21672145, 51733007), and Natural Science Foundation of Shanghai (19ZR1412300, 17JC1403700).

语种：英文

摘要：An efficient and convenient cobalt-catalyzed ortho-C(sp(2))-H amidation of benzaldehydes employing dioxazolones as the aminating reagent has been developed. The key feature of this protocol is the use of green and economic earth-abundant metals cobalt as the catalyst with the p-chloroaniline as the transient directing group. Further application of our approach was demonstrated by the synthesis of C1r serine protease inhibitor 45 and elastase inhibitor 49.