文献类型：期刊文献

英文题名：Irreversible Electroporation Enhanced by Radiofrequency Ablation: An In Vitro and Computational Study in a 3D Liver Tumor Model

作者：Fang, Zheng[1];Mao, Huimin[2];Moser, Michael A. J.[3];Zhang, Wenjun[4];Qian, Zhiqin[2];Zhang, Bing[1]

机构：[1]Shanghai Univ, Sch Mechatron Engn & Automat, Energy Based Tumor Ablat Lab, 99 Shangda Rd, Shanghai 200444, Peoples R China;[2]East China Univ Sci & Technol, Sch Mech & Power Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Univ Saskatchewan, Dept Surg, Saskatoon, SK, Canada;[4]Univ Saskatchewan, Div Biomed Engn, Saskatoon, SK, Canada

年份：2021

卷号：49

期号：9

起止页码：2126

外文期刊名：ANNALS OF BIOMEDICAL ENGINEERING

收录：;EI(收录号：20210809953066);WOS:【SCI-EXPANDED(收录号:WOS:000618594000002)】；

基金：This article was supported in part by the National Natural Science Foundation of China through a Funding Grant (Grant No. 81801795) to the corresponding author (BZ) and the Program of Production, Research and Development of Minhang District of Shanghai through a Funding Grant (Grant No. 2019MHC107) to the corresponding author (ZQ).

语种：英文

外文关键词：Irreversible electroporation; Radiofrequency ablation; Tumor ablation enhancement; 3D liver tumor model; Finite element model

摘要：In the present study, we used a computational and experimental study in a 3D liver tumor model (LTM) to explore the tumor ablation enhancement of irreversible electroporation (IRE) by pre-heating with radiofrequency ablation (RFA) and elucidate the mechanism whereby this enhancement occurs. Three ablation protocols, including IRE alone, RFA45 -> IRE (with the pre-heating temperature of 45 degrees C), and RFA60 -> IRE (with the pre-heating temperature of 60 degrees C) were investigated. Both the thermal conductivity and electrical conductivity of the 3D LTM were characterized with the change in the pre-heating temperature. The results showed, compared to IRE alone, a significant increase in the tumor ablation volume (19.59 +/- 0.61 vs. 15.29 +/- 0.61 mm(3), p = 0.002 and 22.87 +/- 0.35 vs. 15.29 +/- 0.61 mm(3), p < 0.001) was observed with both RFA45 -> IRE and RFA60 -> IRE, leading to a decrease in lethal electric filed strength (8 and 17%, correspondingly). The mechanism can be attributed to the change of cell microenvironment by pre-heating and/or a synergistic effect of RFA and IRE. The proposed enhancing method might contribute to the improvement of interventional oncology in the treatment of large tumors close to critical organs (e.g., large blood vessels and bile ducts).