文献类型：期刊文献

英文题名：Biodegradable Nanobowls with Controlled Dents

作者：Jiang, Jinhui[1,2]; Sun, Min[2]; Gu, Qianxi[2]; Liu, Shangning[2]; Sun, Hui[3]; Fan, Zhen[2]; Zhu, Yunqing[2]; Du, Jianzhong[1,2,4]

机构：[1] Department of Gynaecology and Obstetrics, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology, Perioperative Medicine Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200434, China; [2] Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, 4800 Caoan Road, Shanghai, 201804, China; [3] State Key Laboratory of High-Efficiency Coal Utilization and Green Chemical Engineering, School of Chemistry and Chemical Engineering, Ningxia University, Yinchuan, 750021, China; [4] School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China

年份：2025

卷号：14

期号：1

起止页码：35

外文期刊名：ACS Macro Letters

收录：EI(收录号：20250417740768)

语种：英文

外文关键词：Grafting (chemical) - Nanoclay - Theranostics

摘要：Nanobowls show promising potential in biomedical applications, such as bioimaging, cargo delivery, and disease theranostics, due to their unique concave structure and interior cavities. However, the lack of biodegradable nanobowls with manipulable size (especially the dent size) still exists as an obstacle for their in-depth exploration and application in biomedical fields. Herein, polypeptide-based nanobowls are successfully obtained by the self-assembly of a graft polypeptide [named TPE-P(GAAzo21-stat-GA29)] via a solvent-switch method. Through the synergistic effect between the hydrogen bonding and π-π stacking interactions, the size of nanobowls and the corresponding dents can be facilely controlled by altering either the initial polypeptide concentration or the cosolvents in self-assembly. Furthermore, such polypeptide-based nanobowls are demonstrated to be biocompatible and biodegradable in vitro, which may promote the development of biomedical nanobowls in the future. ? 2024 American Chemical Society.