文献类型：期刊文献

英文题名：Advances in green bioproduction of marine and glycosaminoglycan oligosaccharides

作者：Deng, Chen[1,2];Zhao, Mengxuan[1,2];Zhao, Qiong[1,2];Zhao, Liming[1,2,3,4]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Shanghai Collaborat Innovat Ctr Biomfg Technol SCI, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Sch Pharm, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Sch Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2023

卷号：300

外文期刊名：CARBOHYDRATE POLYMERS

收录：;EI(收录号：20224513070905);WOS:【SCI-EXPANDED(收录号:WOS:000891767600005)】；

基金：This work was supported by the National Key Research and Development Program of China [grant number 2019YFD0901805] ; the Open Project Funding of the State Key Laboratory of Bioreactor Engineering, ECUST [grant number ZDXM2019] ; the Fundamental Research Funds for the Central Universities, the China Postdoctoral Science Foundation [grant number 2022M711144] ; and the 111 Project [grant number B18022] .

语种：英文

外文关键词：Functional oligosaccharide; Activity and application; Green biosynthesis; Enzyme engineering; Synthetic biology

摘要：Functional oligosaccharides are a class of low-polymerization sugars with physiological functions, showing great potential in the fields of food, medicine, and agriculture, with economic and social value. Certain functional oligosaccharides (e.g., marine oligosaccharides and glycosaminoglycan oligosaccharides) are mainly prepared by degradation of natural polysaccharides using physical and chemical methods. These strategies present problems, including harsh reaction conditions, serious pollution, and variations in product quality. Recently, specific techniques have been applied to the green production of functional oligosaccharides. In this paper, the classi-fication and biological effects of marine oligosaccharides and glycosaminoglycan oligosaccharides are firstly introduced. Then, recent research progress and related databases for green biological preparation of marine oligosaccharides and glycosaminoglycan oligosaccharides are reviewed, and optimization strategies for green bioproduction are summarized. Finally, the limitations and prospects of the current green synthesis strategies are discussed.